Moreover, in a model of myocardial infarction, intraperitoneal injection of recombinant OSM (rOSM) improved cardiac function at least in part by promoting the shift of cardiac Mφ from M1 to M2 phenotype [35] and treatment of mice subjected to myocardial infarction with rOSM-alleviated post-infarction cardiac remodeling through the enhancement of cardiomyocyte autophagy [36]. The gene discussed is OSM; the disease is myocardial infarction.