Those studies demonstrated that the liver is the main target of AAV-LAV-BPIFB4 infection, which is also followed by (i) a rapid rise in the plasma level of the BPIFB4 protein [25], (ii) BPIFB4 enrichment in CD11b+ myeloid cells both in bone marrow and in blood without any mRNA upregulation (either human or murine), (iii) over-expression of the human protein in most tissues of transfected mice, such as the aorta and heart [22,25,26], and an increase in BPIFB4 in myocytes and vascular cells [22]. This evidence concerns the gene BPIFB4 and infection.