Our observation of a reduced rate of epigenetic aging in blood cells corroborates the rejuvenating effect of the LAV gene therapy on the immune system of old mice, demonstrated by decreased senescence among the peripheral blood mononuclear cells, restored NAD+ plasmatic levels and reduced CD38+ macrophages after 60 days of AAV-LAV-BPIFB4 infection [23]. This evidence concerns the gene CD38 and infection.