The reasons for the elevated levels of Lp-PLA2 in individuals with obesity can be speculated as follows: Macrophages have the potential to infiltrate adipose tissue within the intra-abdominal or visceral cavities, thereby substantially contributing to the inflammatory state that is associated with metabolic syndrome and abdominal obesity [17]. This evidence concerns the gene PLA2G7 and obesity due to melanocortin 4 receptor deficiency.