In metastatic prostate cancer, for example, tumor extracellular vesicles migrate to the bone, where the absorption of miR-378a-3p from these vesicles by bone marrow macrophages initiates the process of osteolysis along the Dyrk1a/Nfatc1 pathway, which in turn contributes to an increase in Angptl2 secretion and tumor progression [121]. The gene discussed is ANGPTL2; the disease is neoplasm.