PFKFB3 and carcinoma: Aiming to define the possible metabolic differences between the groups, we compared the correlation indices of the tested metabolism genes among them and found a significant difference in the correlations between PRDX3 and PFKFB3 between hyperplasia and carcinoma, suggesting that, the normal co-regulation of the response to mitochondrial oxidative stress and the glycolytic flux, which maintains metabolic homeostasis, is disrupted in carcinoma patients.