BCL2 and cancer: Overall, it can be concluded that SnEA and pyrogallol were potentially responsible for the anti-cancer action seen in both types of CRPC cells, via disruption of the ΔΨm and decreased expression of anti-apoptotic proteins (survivin, Bcl-xl, and Bcl-2) leading to activation of the intrinsic apoptosis signaling cascade (caspases-9, caspases-3, and PARP-1).