Pnpla2 was significantly upregulated (p < 0.05) in liver hepatocellular carcinoma (LIHC), prostate adenocarcinoma (PRAD), thyroid carcinoma (THCA), and cholangiocarcinoma (CHOL), while significantly downregulated (p < 0.05) in breast invasive carcinoma (BRCA), head and neck squamous cell carcinoma (HNSC), kidney chromophobe (KICH), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC) and pheochromocytoma and paraganglioma (PCPG). This evidence concerns the gene PNPLA2 and squamous cell lung carcinoma.