We focused our attention on the 2 top genes identified as overexpressed in both time points with the highest B statistic: Cd9, which encodes an endothelial tetraspanin protein that, although expressed in a variety of cell types, is particularly high in ECs [24,25], where it plays a crucial role in the transendothelial migration of leukocytes [24,26,27]; and Mylip, which encodes a novel ERM-like protein that interacts with myosin regulatory light chain, that inhibits neurite outgrowth [28] and shown to be overexpressed in pericytes during tumour progression [29]. This evidence concerns the gene MYLIP and neoplasm.