Clinically significant elevations of Thl cytokines (IFN-γ, endotoxin, TNF-α, and IL-1β) above baseline disrupt normal cholesterol reverse transport (OTC) and cholesterol outflow and are associated with a higher risk of coronary heart disease (CHD), acute myocardial infarction (MI), and heart failure [130,131]. This evidence concerns the gene IL1B and coronary artery disorder.