In the preventive trial with DSS-colitis, dexamethasone-induced an increase in Hif1a and Il6, and a decrease in Tjp1 expression compared to controls, while Tgfb1 and Vegfa expression was increased in the MTADV group, as well as Nos2 and Tjp1 in comparison to dexamethasone (Figure 5D). Here, NOS2 is linked to colitis.