CA5B and clostridium difficile infection: Although Abderemane-Ali et al. [203] suggest that the N-terminal cytoplasmic region [98,148,167,190] and Cavβ/I-II loop complex [97,161,200] affect CDI, how conformational changes in these cytoplasmic regions lead to CDI remains unsolved [97,161,196,197,204,205].