Epilepsy-related genes involved in the circadian entrainment and glutamatergic synapse pathways are down-regulated in TLE mice (Figure 1D), as shown by the expression of Grin2a (Glutamate ionotropic receptor NMDA type subunit 2A), Gria2 (Glutamate ionotropic receptor AMPA type subunit 2), Kcnj3 (Potassium inwardly rectifying channel subfamily J member 3), and Grin1 (Glutamate ionotropic receptor NMDA type subunit 1), in TLE and control (CTL) mice (Figure 1F). The gene discussed is GRIA2; the disease is epilepsy.