SOX5 can suppress PDGFB (platelet-derived growth factor B)-induced glioma development in mice by inhibiting cell proliferation and inducing acute cellular senescence through the regulation of p27Kip1 (cyclin-dependent kinase inhibitor 1B) and AKT1 (AKT serine-threonine protein kinase) [51]. Here, SOX5 is linked to central nervous system cancer.