Convincing evidence regarding the potential role of HNE in ischemic stroke was also provided by Guo et al. [75], who used aldehyde dehydrogenase 2 (ALDH2)-deficient stroke-prone spontaneously hypertensive rats as experimental models to prove that ALDH2 activation leads to HNE catabolism, which provides neuroprotection. Here, ALDH2 is linked to ischemic stroke.