Although TSHZ2 and CCDC80 had a powerful discrimination ability (AUCTSHZ2 = 0.977; AUCCCDC80 = 0.833) in GSE53408 (Figure 3B), we did not select these two genes, due to the sequence uncertainty of TSHZ2 and the certainty of the correlation between CCDC80 and PAH. The gene discussed is TSHZ2; the disease is pulmonary arterial hypertension.