The association between the biological tumor volume, as determined by different techniques including contrast-enhanced volume on T1-weighted images, FLAIR hyperintense volume, and 3,4-dihydroxy-6-18F-fluoro-L-phenylalanine (18FDOPA) hypermetabolic volume and the OS of IDH wild-type HGG patients has been studied by Tatekawa and co-workers [31]. Here, IDH1 is linked to neoplasm.