BCL2L1 and cancer: However, it has been shown that several cancer senescent cell types, such as triple-negative breast cancer cell lines and pilocytic astrocytoma tumor cells, exhibit high levels of the Bcl-xL protein [43,44], as well as in both pancreatic intraepithelial neoplasia (PanIn) and pancreatic ductal adenocarcinoma (PDAC) [45].