Although the correlation between polyploidy and resistance to Bcl-xL-mediated apoptosis has not been reported, it has been described that the inhibition of Bcl-xL reduces the viability of polyploid lymph node carcinoma of the prostate cancer cells and that the survival of polyploid tumor cells depends on Bcl-xL [80] (Figure 4A). This evidence concerns the gene BCL2L1 and neoplasm.