Interestingly, among the 167 significant canonical pathways identified by IPA (p-value 0.05), the following had absolute z-scores greater than 2.0, phagosome formation, CREB signaling in neurons, cardiac hypertrophy signaling, neuroinflammation signaling pathway and TREM signaling were enriched, indicating that they were strongly associated to T2D in the obese individuals with T2D (Figure 8). Here, CREB1 is linked to type 2 diabetes mellitus.