In liver cancer cells, alpha-enolase 1 (ENO1), a glycolytic enzyme, was found to suppress the expression of iron regulatory protein 1 (IRP1) by binding to the 5′ UTR of its mRNA, recruiting the CCR4-NOT deadenylase complex to the 3′ UTR and accelerating IRP1 mRNA degradation [146]. This evidence concerns the gene ACO1 and liver cancer.