In the same study, hypoxia led to an increase in the alternative splicing of eS24/RPS24 in U87MG (glioblastoma) and PC3 (prostate cancer) monolayers and spheroids relative to normoxia, which resulted in the removal of three amino acids at the C-terminus, including a lysine [138]. The gene discussed is RPS24; the disease is Familial prostate cancer.