IGF1 was shown to increase erythropoiesis by binding to the IGF1R expressed by erythroblasts in several development stages [116], whereas the possible role of IL-18 in erythropoiesis has still not been investigated, even though the expression of IL-18R has been detected in erythroid lineage cells and the production of IL-18 may be stimulated in SCD by heme-activated inflammasome formation [117]. The gene discussed is IL18; the disease is Schnyder corneal dystrophy.