FBXW7 and cancer: FBXW7 acts as a potent tumor suppressor that may control the expression levels of multiple oncoproteins (i.e., mTOR, notch, cyclin E, c-Myc, and c-Jun) that engage in cellular signaling pathways by inducing them for ubiquitin-mediated proteasomal degradation, thereby protecting against cancer development [27,28].