Our recent study found that the acute infection of FMDV resulted in the death of all mice within 72 h post-inoculation (hpi) [18]; thus, we first analyzed the mRNA expression of CXCL13 in the heart, liver, spleen, lung, and kidney collected from mock mice and FMDV-infected mice at 12, 24, 36, 48, 60, and 72 hpi. The gene discussed is CXCL13; the disease is infection.