Furthermore, in IL-10-/- BMDMs derived from IL-10-/- mice, the CXCL13 protein concentration was significantly decreased compared that in wild-type BMDMs after FMDV infection (FMDV-Wild type group vs. FMDV-IL-10-/- group: 2158.0 ± 257.7 vs. 1175.1 ± 113.7 pg/mL, respectively, n = 3, p < 0.05) (Figure 4D). The gene discussed is CXCL13; the disease is infection.