While the data concerning the changes in the expression of CDNF in various CNS disorders are scarce, interesting studies are showing that CDNF alleviates ER stress-induced cellular damage and suppresses the secretion of pro-inflammatory cytokines from astrocytes [69], thus promoting recovery and survival of midbrain dopaminergic neurons in animal models of PD [70,71]. Here, CDNF is linked to central nervous system disorder.