For example, both 8-OHdG and γ-H2AX can be induced by PD-associated neurotoxins, including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, paraquat, and 6-hydroxydopamine (6-OHDA) [28,29,30,31,32,33]. Here, H2AX is linked to Parkinson disease.