In addition, the secretive activity in both male and female monocytes is influenced by androgens: the chronic administration of Te in hypogonadal type II diabetes mellitus (T2DM) patients causes the reduction, or complete abrogation, in the secretion of the monocyte pro-inflammatory cytokines IL-6, IL-1β, and TNF-α [29]. This evidence concerns the gene IL1B and type 2 diabetes mellitus.