Nevertheless, it has been found that homozygous carriers of the CHIT-1 polymorphism, which generate the reduction of CHIT-1 expression, do not exhibit decreased ALS severity, indicating that CHIT-1 is a neuroinflammatory marker rather than being actively involved in ALS pathogenesis (Figure 2) [110,111]. Here, CHIT1 is linked to amyotrophic lateral sclerosis.