In addition, CHI3L1 has been linked with neuroinflammatory proteins associated with AD progression, such as metalloproteinase-10 (MMP-10) [66], CX3CL1 [67], eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) [68], and CSF-1 (Figure 1) [69]. This evidence concerns the gene CHI3L1 and Alzheimer disease.