PIK3CB and gastric neoplasm: In fact, P70S6K1 expression was associated with advanced gastric tumors (pT3-pT4 tumors; p = 0.03); meanwhile, the levels of PI3K, AKT, p-AKT, P70S6K1, p-P70S6K1, and eIF4E were higher in tumors with lymph node metastases (p ≤ 0.01 for all) [29].