PIK3CA and neoplasm: Similarly, the overexpression of FOXD1-AS1 has been described as accelerating the processes of tumor growth, metastasis, and chemoresistance on in vitro and in vivo GC models through two mechanisms: (1) the induction of FOXD1 translation (previously explained) and (2) the role of FOXD1-AS1 as a sponge of miR-466 in GC cells, thereby producing an increase in the expression of one of the targets of miR-466: the PIK3CA gene.