RPS6KB1 and neoplasm: Immunohistochemistry (IHC) analyses showed that PI3K, AKT, p-AKT, p-mTOR, p-4E-BP1, P70S6K1, p-P70S6K1, eIF4E, and p-eIF4E proteins were significantly overexpressed in tumor tissues compared to adjacent non-tumoral tissues (p < 0.05 for all) [18,29].