At any rate, some caution is needed in extrapolating data obtained from models in which PCOS is experimentally triggered by using either androgen administration or continuous light exposure; results provided by the aforementioned study demonstrated that high doses of D-Chiro-Ins supplementation profoundly altered ovarian histology, increased serum testosterone levels, and reduced aromatase levels. The gene discussed is CYP19A1; the disease is polycystic ovary syndrome.