TNF and metabolic syndrome: A randomized placebo-controlled clinical trial in elderly patients with metabolic syndrome indicated that supplementation with L. plantarum, L. acidophilus, L. reuteri, in combination with inulin and fructooligosaccharide, improved their visceral adiposity, reduced their waist circumference, lowered their lipid profile (TC, HDL-C, triglycerides), hs-CRP and TNF-α, and reduced their metabolic syndrome and blood pressure [104].