Regarding HCC, G2/M cell cycle arrest and elevated ROS production have recently been reported, and were regarded as the consequence of DNA damage and the increased expression of thioredoxin reductase-1 (TrxR-1) and heme oxygenase (HO)-1 (HO-1) [22,23]. The gene discussed is TXNRD1; the disease is hepatocellular carcinoma.