RNF41 and COVID-19: Apart from the elevated plasma proteins, we also identified several downregulated proteins after a SARS-CoV-2 infection, among which, besides the abovementioned RNF41, surprisingly, the inflammatory cytokine IL-17A was found to be increased in DCs but reduced in patients with COVID-19 with comorbidities compared to their DCs (Figure 1c, Figure 5a and Figure S3).