Moreover, extracellular matrix proteins were found to be upregulated in patients with COVID-19 that indicates the potential tissue damage and remodeling due to a SARS-CoV-2 infection such as the pro-inflammatory TNC [88], COL6A3, MATN2 and THBS4/TSP4, which are involved in tissue regeneration and wound healing [89], not previously found in patients with COVID-19. The gene discussed is THBS4; the disease is COVID-19.