To distinguish which of the protein changes were due to an altered secretion from a certain type of cells and which were a result of destructed tissues or cells due to the viral infection, from the 116 DEPs, 30 proteins were identified in the human blood secretome, such as FOLR2, GRN, EFNA4, TNFSF13B, CCL26, CCL21, PILRA, VWF, LTBP3, LILRA5 and TGFA (Table S2). This evidence concerns the gene EFNA4 and viral infectious disease.