Simultaneously, some immune suppressors are upregulated that potentially dampen the immune response, such as VSIG4 inhibiting macrophages and T cell cytotoxicity [71,72,73], PILRA that was previously found to be upregulated in monocytes from severe-stage patients with COVID-19 [74], and SIGLEC9 that potentially inhibits NK cells and neutrophils [75,76]. The gene discussed is SIGLEC9; the disease is COVID-19.