Moreover, TMEM97 expression is significantly increased by ~1.5-fold in Alzheimer’s disease and is localized to an increased proportion (~1.8-fold) of synapses in brain tissue from individuals with Alzheimer’s disease when compared with healthy controls [65], which suggests a potential compensatory response to Alzheimer-related synaptic loss [69]. The gene discussed is TMEM97; the disease is early-onset autosomal dominant Alzheimer disease.