Alzheimer’s disease is a progressive neurodegenerative disorder characterized by several pathological hallmarks, including amyloid-β pathology, tau pathology (i.e., neurofibrillary tangles), and inflammation, in which individuals present with cognitive dysfunction, memory loss, dementia, and the impairment of daily living activities [19]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.