Furthermore, the set of significant genes represented in the MEdarkred module (Supplementary Table S10) across EOD, SOFA, BUN, and heart failure, alcohol liver disease, and kidney disease comorbidity include gene markers such as AMAD9, KIF1B, SLC22A4, MAPK14, MAP2K6, SLC2A3, ILI7RA, which have been associated with COVID-19 disease severity, tissue injury, and sepsis. This evidence concerns the gene MAP2K6 and kidney disorder.