Furthermore, the set of significant genes represented in the MEdarkred module (Supplementary Table S10) across EOD, SOFA, BUN, and heart failure, alcohol liver disease, and kidney disease comorbidity include gene markers such as AMAD9, KIF1B, SLC22A4, MAPK14, MAP2K6, SLC2A3, ILI7RA, which have been associated with COVID-19 disease severity, tissue injury, and sepsis. The gene discussed is SLC22A4; the disease is heart failure.