The aims of this study are to unveil whether the effect of full-length androgen receptor (ARFL) and splicing variant 7 AR (ARv7) on the expression of MALT1 is androgen-dependent or androgen-independent, and, furthermore, to evaluate the potential ARv7/MALT1/NF-κB-signaling pathway in human prostate cancer cells. This evidence concerns the gene NFKB1 and prostate cancer.