AR and Familial prostate cancer: A recent study has elucidated that caffeic acid phenethyl ester, a bioactive component of propolis with antagonistic activity to androgen and NF-κB, blocked MALT1 expression via androgen and NF-κB signaling, suggesting that MALT1 may have a critical role in the crosstalk between AR and NF-κB signaling in human prostate cancer cells in vitro and in vivo [35].