In this study, we demonstrated that androgen-induced MALT1 expression facilitates the nuclear translocation of the NF-κB subunits, p50 and p65, to stimulate the gene expression of PSA and NDRG1, indicating a novel androgen/ARFL/MALT1/NF-κB-signaling pathway presented in ARFL-positive but not ectopic ARFL-overexpressed AR-negative prostate cancer cells. The gene discussed is MALT1; the disease is Familial prostate cancer.