F5 and blood coagulation disease: Several coagulopathies have been described, including von Willebrand’s disease (von Willebrand factor deficiency), hemophilia A (FVIII deficiency), hemophilia B (FIX deficiency), FXI deficiency, and alterations in other coagulation factors such as fibrinogen, prothrombin, FV, FVII, and FX, among others [49].