Methylenedioxypyrovaleroneconsumption increased horizontal and vertical activity immediately, affected short-term recognition memory, and caused receptor dopamine-mediated memory impairment. Chronic consumption caused sensitization or tolerance to the locomotor effects depending on the route of administration. Dopamine receptors D1 in nucleus accumbens could mediate methylenedioxypyrovaleroneeffects. The gene discussed is DRD1; the disease is memory impairment.