High levels of HIF-1α, resulting from a decrease in its degradation in the presence of tissue hypoxia [5,20,21,22], may be due to the imbalance between the supply and consumption of O2 by the myocardium due to disharmony in the proliferative capacity of the capillary network, vascular rarefaction, the degree of concentric hypertrophy, and myocardial fibrosis [23,24,25,26,27]. The gene discussed is HIF1A; the disease is Myocardial fibrosis.