N-palmitoylated peptides PZ-218 (Palm-MGYQKKLRSMTD) and PZ-210 (Palm-SKLSHSKGHQKRKALK), corresponding to the ICL1 (63–74) and ICL3 (224–239) of CXCR4 inhibited CXCL12/SDF-1-induced responses in human neutrophils and mice and also blocked CXCL12/SDF-1-mediated migration of lymphoma and lymphocytic leukemia cells while palmitate-free analogs were inactive [231,236]. This evidence concerns the gene CXCL12 and lymphoma.