In 2019, the compound S37a with seven centers of chirality was developed, which one of the stereoisomers at micromolar concentrations suppressed the AC activity and the cAMP accumulation in HEK293 cells with expressed TSHR when they were treated with TSH and stimulatory monoclonal antibodies TSAb M22 and KSAb1, oligoclonal stimulatory antibodies TSAb characteristic of patients with Graves’ disease, as well as a small C2 agonist [323]. This evidence concerns the gene TSHR and Graves disease.