It has been shown that in the blood of patients with systemic sclerosis, a severe autoimmune disease, autoantibodies to ICL2 and ICL3 and the membrane-proximal region of the cytoplasmic C-terminal domain of CXCR3 predominate, while in healthy subjects the proportion of autoantibodies to extracellular regions of this receptor was significantly higher [242]. Here, CXCR3 is linked to systemic sclerosis.