Changes in oestrogen and testosterone metabolism and the LH, FSH and SHBG levels after bariatric surgery result in the improvement of polycystic ovary syndrome (96% resolution) and fertility in premenopausal women, a potential decrease in future oestrogen-sensitive cancers in women and hypogonadism (87% resolution) in males [72,89]. The gene discussed is PLOD1; the disease is cancer.