In experimental models of HD, chronic administration of THI resulted in mitigation of motor deficits, activation of prosurvival signaling pathways (demonstrated among others by increased phosphorylation of kinase AKT and enhanced level of BDNF), preservation of white matter integrity and proper synaptic activity in R6/2 mice, while amelioration of locomotor function and increased lifespan in a D. melanogaster HD model [135]. Here, AKT1 is linked to Huntington disease.