Decreased expression of genes coding for long chain base subunit 1 of serine palmitoyltransferase (SPTLC1) and ceramide synthase 1 (CerS1) was figured out in the striatum and cortex of R6/2 mice (the first transgenic mouse model of HD), which was subsequently reflected in a significant reduction in dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide C18:0 (dhCer) in both studied brain regions [76]. Here, CERS1 is linked to Huntington disease.