JAK2 and B-cell chronic lymphocytic leukemia: Other findings revealed that in B-cell chronic lymphocytic leukemia (B-CLL), JAK2 on the surface of B cells promoted cell adhesion and survival in bone marrow stromal niches by activating αLβ2 and α4β1 integrins, mediating B-cell-dependent adhesion and depression in secondary lymphoid-like organs [204].