Furthermore, previous research showed that IL-2 stimulated the expression of α4β7 integrins on NK cells, which participated in the myocardial infarction repair process via promoting TNF-α-stimulated endothelial cell proliferation, enhancing collagen synthesis and angiogenesis, thereby reducing fibrosis within the infarcted myocardium, which may provide a novel approach for the treatment of myocardial infarction [150]. The gene discussed is TNF; the disease is myocardial infarction.