Surprisingly, we were not able to detect elevated autoAbs against LEDGF/p75 by IFA and LIA in patients with PCa or bladder cancer (BCa), but we observed a significant increase in autoAb reactivity against LEDGF/p75 over-expressing cells in sera of patients with benign prostatic hyperplasia (BPH). Here, PSIP1 is linked to urinary bladder cancer.