Lens epithelium-derived growth factor (LEDGF) splice variant of 75 kDa (LEDGF/p75), also known as transcriptional co-activator p75, PC4, and SFRS1 interacting protein (PSIP1), is a multifunctional stress-response protein acting as a transcriptional co-activator over-expressed in distinct tumor and inflammatory conditions [1]. Here, PSIP1 is linked to neoplasm.