These vasculature genes included Efnb2, a member of the ephrin family and a pro-angiogenic factor whose overexpression predicts the poor prognosis of solid tumors [43,44,45], and Id1, a helix–loop–helix transcription factor that regulates tumor angiogenesis [46] (Figure 4E,F). The gene discussed is EFNB2; the disease is neoplasm.