CYP24A1 and hypophosphatemia: Thus, abnormally elevated levels of CYP24A1 can create a deficit in vitamin D levels, since this enzyme is uniquely responsible for the catabolism of vitamin D. Elevated levels of CYP24A1 are observed in breast, prostate, esophageal, colon, and lung cancers [129,130], genetically linked hypophosphatemia [131,132], diabetic nephropathy [133,134], and CKD [135,136].