LMNA and heart failure: Despite the observed pattern of lipid accumulation in the myocardial tissue, no significant changes in the triglyceride levels were noted in the circulating serum, demonstrating that (1) Lmna-deleted CMs accumulate lipids at 2 weeks post Tam, (2) this increase in accumulation is not due to overall higher lipid levels in the circulation, and (3) the pattern of lipid accumulation in our induced CM-Lmna deletion mice recapitulates the phenotype in the human disease of heart failure.