ALB and neoplasm: They designed cascade two-stage re-oxygenation and immune re-sensitization BSA-MHI148@SRF NP, with a near-infrared photodynamic dye MHI148, chemically modified with bovine serum albumin (BSA) and multi-kinase inhibitor Sorafenib (SRF), to serve as a novel tumor oxygen and immune microenvironment regulation drug [57].