LMHFV appeared to downregulate 0.35 ± 0.12-fold (p = 0.062) ESR2 expression in AF cells, while in NP cells it was downregulated by either E2 (0.12 ± 0.08-fold, p = 0.062) or LMHFV alone (0.31 ± 0.15-fold, p < 0.05; Figure 2C). Here, ESR2 is linked to atrial fibrillation.