Aggrecan (ACAN) was not altered in the AF, but was slightly upregulated by E2 alone or E2 + LMHFV in the NP (7.5 ± 6.6- and 13 ± 7.1-fold, respectively, p = 0.062; Figure 3C). The gene discussed is ACAN; the disease is atrial fibrillation.