In this study, the blockage of NK1R provided protection to mice against sepsis-induced inflammation in the lungs as the treatment of SR140333 or L703606 both led to a significant reduction in the levels of the production of chemokines and adhesion molecules alongside the subsequent infiltration of neutrophils and the release of proinflammatory cytokines in the lungs. The gene discussed is TACR1; the disease is Sepsis.