Increased expression of GYS2, the isoform found in the liver, has been associated with increased glycogen content in HCC; however, in contrast to clear cell renal cell carcinoma, GYS2 overexpression correlated with decreased cell proliferation, possibly through activation of the p53 signaling pathway by competitive binding to MDM2 to inhibit the ubiquitination of p53 [82]. This evidence concerns the gene TP53 and hepatocellular carcinoma.