In addition, we recently reported an AD family carrying a heterozygous nonsense mutation in ADAM10 (p.Tyr167*), in which the affected siblings exhibited a 50% decrease in ADAM10 levels (species of 50 and 55 kDa), and decreased α-secretase activity (as determined by reduced levels of sAPPα) in CSF [24]. Here, ADAM10 is linked to Alzheimer disease.